For individuals who have knee osteoarthritis who receive an injection of suspension or particulate
formulation of HAM or amniotic fluid, the evidence includes a feasibility study. Relevant outcomes are
symptoms, functional outcomes, quality of life, and treatment-related morbidity. The pilot study assessed
the feasibility of a larger RCT evaluating HAM injection. Additional trials, which will have a larger sample
size and longer follow-up, are needed to permit conclusions on the effect of this treatment. The evidence
is insufficient to determine the effects of the technology on health outcomes.

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