Neurotrophic Keratitis with Ocular Surface Damage and Inflammation That Does Not Respond to Conservative Therapy

For individuals who have neurotrophic keratitis with ocular surface damage and inflammation that does
not respond to conservative therapy who receive HAM, the evidence includes an RCT. Relevant outcome
are symptoms, morbid events, functional outcomes, and quality of life. An RCT of 30 patients showed no
benefit of sutured HAM graft compared to tarsorrhaphy or bandage contact lens. Based on clinical input,
HAM might be considered for patients who did not respond to conservative therapy. Clinical input
indicated that non-sutured HAM in an office setting would be preferred to avoid a delay in treatment
associated with scheduling a surgical treatment. The evidence is sufficient to determine that the
technology results in a meaningful improvement in the net health outcome.

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